Best Treatments for Under-Eye Rejuvenation: From Polynucleotides to PRP
The under-eye area is one of the most delicate and expressive parts of the face — and often the first to show signs of ageing. Whether you're concerned about fine lines, crepey skin, pigmentation, puffiness, or volume loss, modern non-surgical treatments can help restore brightness, firmness, and smoothness.
Here’s a guide to the most effective under-eye treatments, including polynucleotides, PRP, microneedling, exosomes and more — with a focus on results-driven, minimally invasive solutions.
1. Polynucleotides (PNs)
Best for: Crepey skin, thinning, early wrinkles, loss of firmness
Polynucleotides are purified DNA fragments that stimulate fibroblasts, boosting collagen, elastin, and tissue repair. Injected into the under-eye area, they gradually thicken and strengthen the skin, improving elasticity and hydration.
This regenerative treatment is ideal for delicate, ageing skin and is especially effective for fine lines and texture concerns.
✦ Results: Gradual improvement over 6–12 weeks
✦ Benefits: Firmer, smoother, more resilient skin
✦ Downtime: Minimal; mild swelling or bruising possible
2. PRP (Platelet-Rich Plasma) Injections
Best for: Dark circles, pigmentation, thinning skin, tired appearance
PRP uses the patient’s own blood plasma, concentrated with growth factors, to stimulate skin repair. When injected under the eyes, it improves skin tone, circulation, and collagen production — making it especially helpful for vascular dark circles or early hollowing.
Unlike some treatments, PRP can be injected right up to the lower lid margin, allowing precise treatment of delicate areas. It's also 100% natural and suitable for sensitive skin.
✦ Results: After 2–4 sessions
✦ Benefits: Brightens, firms, improves skin quality
✦ Downtime: Mild puffiness or bruising may occur
3. Microneedling with Targeted Serums
Best for: Fine lines, poor texture, dullness, early signs of pigmentation
Microneedling creates controlled micro-channels in the skin, stimulating natural collagen production and improving absorption of active ingredients.
When paired with targeted serums, results can be further enhanced:
Anti-ageing serums with peptides and hyaluronic acid improve elasticity and hydration
Brightening serums with ingredients like vitamin C or tranexamic acid target pigmentation and dullness
✦ Results: Build over 2–4 sessions
✦ Benefits: Smoother texture, improved tone, refreshed appearance
✦ Downtime: Mild redness or swelling for 1–2 days
4. Anti-Wrinkle Injections
Best for: Crow’s feet and dynamic lines at the outer eye corners
Botulinum toxin softens expression lines caused by repetitive movement, especially around the outer corners of the eyes. It prevents deeper wrinkles and refreshes the eye area without affecting natural expression.
✦ Results: Seen in 3–7 days, lasting up to 4 months
✦ Benefits: Smooths lines, opens the eye area
✦ Downtime: Minimal
5. Mesotherapy
Best for: Dehydration, dullness, early signs of ageing
Mesotherapy delivers a blend of hyaluronic acid, vitamins, and peptides directly into the under-eye area via tiny injections. It’s a good option for improving hydration, texture, and brightness in younger or early-ageing skin.
✦ Results: Seen after 2–3 sessions
✦ Benefits: Hydrated, refreshed appearance
✦ Downtime: Low
6. Exosomes
Best for: Inflammation, sensitive or tired-looking skin
Exosomes are regenerative vesicles rich in growth factors and peptides. They help repair skin, reduce inflammation, and support healing. Often used in combination with microneedling for better delivery and absorption.
✦ Results: Develop over 4–6 weeks
✦ Benefits: Calms, brightens, supports regeneration
✦ Downtime: Minimal
7. Chemical Peels (Low-Strength)
Best for: Pigmentation, uneven tone, mild texture issues
Gentle peels using ingredients like lactic acid or low-strength TCA can reduce pigment and smooth skin around the eyes. These are carefully selected for safety in this sensitive area.
✦ Results: After 2–3 treatments
✦ Benefits: Brighter tone, smoother surface
✦ Downtime: Mild peeling or dryness
Choosing the Right Treatment for Under-Eye Concerns
Concern
Recommended Treatment(s)
Crepey skin / thinning
Polynucleotides, Microneedling + anti-ageing serum
Dark circles (vascular or pigment)
PRP injections, Brightening serums, Light chemical peels
Crow’s feet (expression lines)
Botox
Early hollowness / tired appearance
PRP, Polynucleotides, Mesotherapy
Dull or dehydrated under-eyes
Mesotherapy, Exosomes, Microneedling
Final Thoughts
Under-eye rejuvenation requires a precise and gentle approach. Whether you're concerned about pigmentation, lines, or loss of firmness, there are effective non-surgical options to restore a brighter, healthier look. Treatments like polynucleotide injections, targeted microneedling, and PRP can be used alone or in combination — tailored to your skin type and goals.
Always consult a qualified medical professional for a personalised plan and safe treatment around the delicate eye area.
Dr Syreeta Daw
Professional Doctor specialising in Skin, Hair & Health
