Why Polynucleotides Are the Future of Natural Skin Rejuvenation
In the world of aesthetic and regenerative medicine, polynucleotides are generating a real buzz — and for good reason. While many skin treatments offer short-term fixes or quick cosmetic enhancements, polynucleotides work with your skin at a cellular level to actually repair and regenerate tissue. It’s no longer just about “anti-ageing” — it’s about healthy, functional skin that acts and looks younger.
So, what exactly are polynucleotides, and why are they being called the next big thing in skin rejuvenation?
What Are Polynucleotides?
At their core, polynucleotides are fragments of DNA derived from natural sources — often salmon DNA, which is incredibly similar to our own and well tolerated by the body. These purified molecules don’t just sit in the skin; they communicate with it, encouraging repair, hydration, and collagen production.
That means you’re not just covering up signs of ageing — you’re helping your skin function better from within.
They’re already well established in other fields of medicine, like ophthalmology and wound healing, but it’s their move into aesthetic practice that’s exciting so many practitioners and patients alike.
How Do They Work?
Think of polynucleotides as skin whisperers. Once injected, they stimulate your skin’s fibroblasts — the hardworking cells responsible for producing collagen and elastin. Over time, this improves structure, tone, and texture.
But they also do more:
Hydration boost: PNs are hydrophilic, meaning they attract and hold onto water molecules. This gives the skin a plumper, dewier look almost immediately.
Anti-inflammatory action: They reduce oxidative stress and support healing, which is particularly helpful for sensitive or inflamed skin.
Tissue regeneration: With continued use, you see real improvements in skin resilience, elasticity, and thickness — not just superficial changes.
What’s really unique is how versatile they are. Unlike some treatments that are limited to certain areas, polynucleotides can be safely used in delicate regions like under the eyes, on the neck, and even on the backs of the hands.
What Results Can You Expect — and When?
One of the most important things to understand about polynucleotide treatment is that the results aren’t instant — and that’s actually a good thing. Instead of an artificial “quick fix,” you’re getting progressive, natural rejuvenation.
Here’s a general timeline:
Day 1–3: Mild swelling or redness is common. Some people feel their skin looks more hydrated almost immediately.
Weeks 2–4: That “post-treatment glow” starts to kick in, with smoother texture and subtle radiance.
Weeks 6–8: Collagen production is now in full swing. You may see reduced fine lines, better elasticity, and healthier skin tone.
12+ weeks: Skin looks and behaves more like it did years ago — firmer, thicker, more vibrant.
Most people benefit from a course of 2–3 sessions spaced around 3–4 weeks apart. Top-ups every 6–9 months help maintain those long-term effects.
Who’s It For?
Polynucleotides are ideal for anyone looking for a natural, regenerative approach to skin ageing. Whether you’re noticing fine lines, dullness, or crepey texture — or you just want to support your skin health for the future — this treatment offers a gentle but powerful solution.
It’s especially great for people who:
Prefer subtle, gradual improvement over dramatic change
Want to treat delicate or difficult areas like the under-eyes or neck
Are looking for a complementary treatment alongside microneedling or skin boosters
Value long-term skin health over short-term cosmetic gain
Dr Syreeta Daw
Professional Doctor specialising in Skin, Hair & Health
